The S351 of KIR is phosphorylated, resulting in a mounting affinity of p62 for Keap1 and accompanied by sequestration of Keap1 to the cargoes [75].The Keap1–Cul3–Rbx1 complex has a short while ago been demonstrated to ubiquitylate lysine 420 in the UBA area of SQSTM1, escalating its power to recruit and degrade substrates by autophagy (Lee et a